Executive Order No. 14363. Launching the Genesis Mission

• Executive Order No.: 14363
• Published date: 28 November 2025
• Citation: 90 FR 55035
• Date: 24 November 2025
• Section: Presidential Documents

Presidential Documents

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Executive Order 14363 of November 24, 2025

Launching the Genesis Mission

By the authority vested in me as President by the Constitution and the

laws of the United States of America, it is hereby ordered:

Section 1. Purpose. From the founding of our Republic, scientific discovery

and technological innovation have driven American progress and prosperity.

Today, America is in a race for global technology dominance in the develop-

ment of artificial intelligence (AI), an important frontier of scientific discovery

and economic growth. To that end, my Administration has taken a number

of actions to win that race, including issuing multiple Executive Orders

and implementing America’s AI Action Plan, which recognizes the need

to invest in AI-enabled science to accelerate scientific advancement. In this

pivotal moment, the challenges we face require a historic national effort,

comparable in urgency and ambition to the Manhattan Project that was

instrumental to our victory in World War II and was a critical basis for

the foundation of the Department of Energy (DOE) and its national labora-

tories.

This order launches the ‘‘Genesis Mission’’ as a dedicated, coordinated

national effort to unleash a new age of AI-accelerated innovation and dis-

covery that can solve the most challenging problems of this century. The

Genesis Mission will build an integrated AI platform to harness Federal

scientific datasets—the world’s largest collection of such datasets, developed

over decades of Federal investments—to train scientific foundation models

and create AI agents to test new hypotheses, automate research workflows,

and accelerate scientific breakthroughs. The Genesis Mission will bring to-

gether our Nation’s research and development resources—combining the

efforts of brilliant American scientists, including those at our national labora-

tories, with pioneering American businesses; world-renowned universities;

and existing research infrastructure, data repositories, production plants,

and national security sites—to achieve dramatic acceleration in AI develop-

ment and utilization. We will harness for the benefit of our Nation the

revolution underway in computing, and build on decades of innovation

in semiconductors and high-performance computing. The Genesis Mission

will dramatically accelerate scientific discovery, strengthen national security,

secure energy dominance, enhance workforce productivity, and multiply

the return on taxpayer investment into research and development, thereby

furthering America’s technological dominance and global strategic leadership.

Sec. 2. Establishment of the Genesis Mission. (a) There is hereby established

the Genesis Mission (Mission), a national effort to accelerate the application

of AI for transformative scientific discovery focused on pressing national

challenges.

(b) The Secretary of Energy (Secretary) shall be responsible for imple-

menting the Mission within DOE, consistent with the provisions of this

order, including, as appropriate and authorized by law, setting priorities

and ensuring that all DOE resources used for elements of the Mission are

integrated into a secure, unified platform. The Secretary may designate a

senior political appointee to oversee day-to-day operations of the Mission.

(c) The Assistant to the President for Science and Technology (APST)

shall provide general leadership of the Mission, including coordination of

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participating executive departments and agencies (agencies) through the Na-

tional Science and Technology Council (NSTC) and the issuance of guidance

to ensure that the Mission is aligned with national objectives.

Sec. 3. Operation of the American Science and Security Platform. (a) The

Secretary shall establish and operate the American Science and Security

Platform (Platform) to serve as the infrastructure for the Mission with the

purpose of providing, in an integrated manner and to the maximum extent

practicable and consistent with law:

(i) high-performance computing resources, including DOE national labora-

tory supercomputers and secure cloud-based AI computing environments,

capable of supporting large-scale model training, simulation, and inference;

(ii) AI modeling and analysis frameworks, including AI agents to explore

design spaces, evaluate experimental outcomes, and automate workflows;

(iii) computational tools, including AI-enabled predictive models, simula-

tion models, and design optimization tools;

(iv) domain-specific foundation models across the range of scientific do-

mains covered;

(v) secure access to appropriate datasets, including proprietary, federally

curated, and open scientific datasets, in addition to synthetic data generated

through DOE computing resources, consistent with applicable law; applica-

ble classification, privacy, and intellectual property protections; and Fed-

eral data-access and data-management standards; and

(vi) experimental and production tools to enable autonomous and AI-

augmented experimentation and manufacturing in high-impact domains.

(b) The Secretary shall take necessary steps to ensure that the Platform

is operated in a manner that meets security requirements consistent with

its national security and competitiveness mission, including applicable classi-

fication, supply chain security, and Federal cybersecurity standards and

best practices.

(c) Within 90 days of the date of this order, the Secretary shall identify

Federal computing, storage, and networking resources available to support

the Mission, including both DOE on-premises and cloud-based high-perform-

ance computing systems, and resources available through industry partners.

The Secretary shall also identify any additional partnerships or infrastructure

enhancements that could support the computational foundation for the Plat-

form.

(d) Within 120 days of the date of this order, the Secretary shall:

(i) identify a set of initial data and model assets for use in the Mission,

including digitization, standardization, metadata, and provenance tracking;

and

(ii) develop a plan, with appropriate risk-based cybersecurity measures,

for incorporating datasets from federally funded research, other agencies,

academic institutions, and approved private-sector partners, as appropriate.

(e) Within 240 days of the date of this order, the Secretary shall review

capabilities across the DOE national laboratories and other participating

Federal research facilities for robotic laboratories and production facilities

with the ability to engage in AI-directed experimentation and manufacturing,

including automated and AI-augmented workflows and the related technical

and operational standards needed.

(f) Within 270 days of the date of this order, the Secretary shall, consistent

with applicable law and subject to available appropriations, seek to dem-

onstrate an initial operating capability of the Platform for at least one of

the national science and technology challenges identified pursuant to section

4 of this order.

Sec. 4. Identification of National Science and Technology Challenges. (a)

Within 60 days of the date of this order, the Secretary shall identify and

submit to the APST a detailed list of at least 20 science and technology

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challenges of national importance that the Secretary assesses to have potential

to be addressed through the Mission and that span priority domains con-

sistent with National Science and Technology Memorandum 2 of September

23, 2025, including:

(i) advanced manufacturing;

(ii) biotechnology;

(iii) critical materials;

(iv) nuclear fission and fusion energy;

(v) quantum information science; and

(vi) semiconductors and microelectronics.

(b) Within 30 days of submission of the list described in subsection

(a) of this section, the APST shall review the proposed list and, working

with participating agency members of the NSTC, coordinate the development

of an expanded list that can serve as the initial set of national science

and technology challenges to be addressed by the Mission, including addi-

tional challenges proposed by participating agencies through the NSTC, sub-

ject to available appropriations.

(c) Following development of the expanded list described in subsection

(b) of this section, agencies participating in the Mission shall use the Platform

to advance research and development aligned with the national science

and technology challenges identified in the expanded list, consistent with

applicable law and their respective missions, and subject to available appro-

priations.

(d) On an annual basis thereafter, the Secretary shall review and update

the list of challenges in consultation with the APST and the NSTC to

reflect progress achieved, emerging national needs, and alignment with my

Administration’s research and development priorities.

Sec. 5. Interagency Coordination and External Engagement. (a) The APST,

through the NSTC, and with support from the Federal Chief Data Officer

Council and the Chief AI Officer Council, shall convene relevant and inter-

ested agencies to:

(i) assist participating agencies in aligning, to the extent permitted by

law, their AI-related programs, datasets, and research and development

activities with the objectives of the Mission in their respective areas of

expertise, while avoiding duplication of effort across the Federal Govern-

ment and promoting interoperability;

(ii) identify data sources that may support the Mission’s aim;

(iii) develop a process and resourcing plan in coordination with partici-

pating agencies for integrating appropriate and available agency data and

infrastructure into the Mission, to the extent permitted by law and subject

to available appropriations, including methods under which all agencies

contributing to the Mission are encouraged to implement appropriate risk-

based security measures that reflect cybersecurity best practices;

(iv) launch coordinated funding opportunities or prize competitions across

participating agencies, to the extent permitted by law and subject to avail-

able appropriations, to incentivize private-sector participation in AI-driven

scientific research aligned with Mission objectives; and

(v) establish mechanisms to coordinate research and development funding

opportunities and experimental resources across participating agencies,

ensuring agencies can participate effectively in the Mission.

(b) The APST shall coordinate with relevant agencies in establishing,

consistent with existing authorizing statutes and subject to available appro-

priations, competitive programs for research fellowships, internships, and

apprenticeships focused on the application of AI to scientific domains identi-

fied as national challenges for the Mission, to include placement of program

participants at DOE national laboratories and other participating Federal

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research facilities, with the purpose of providing access to the Platform

and training in AI-enabled scientific discovery.

(c) The Secretary, in coordination with the APST and the Special Advisor

for AI and Crypto, shall establish mechanisms for agency collaboration with

external partners possessing advanced AI, data, or computing capabilities

or scientific domain expertise, including through cooperative research and

development agreements, user facility partnerships, or other appropriate ar-

rangements with external entities to support and enhance the activities

of the Mission, and shall ensure that such partnerships are structured to

preserve the security of Federal research assets and maximize public benefit.

To facilitate these collaborations, the Secretary shall:

(i) develop standardized partnership frameworks, including cooperative

research and development or other appropriate agreements, and data-use

and model-sharing agreements;

(ii) establish clear policies for ownership, licensing, trade-secret protec-

tions, and commercialization of intellectual property developed under

the Mission, including innovations arising from AI-directed experiments;

(iii) implement uniform and stringent data access and management proc-

esses and cybersecurity standards for non-Federal collaborators accessing

datasets, models, and computing environments, including measures requir-

ing compliance with classification, privacy, and export-control require-

ments, as well as other applicable laws; and

(iv) establish procedures to ensure the highest standards of vetting and

authorization of users and collaborators seeking access to the resources

of the Mission and associated research activities, including the Platform

and associated Federal research resources.

(d) The APST, through the NSTC, shall, to the extent appropriate, identify

opportunities for international scientific collaboration to support activities

under the Mission.

Sec. 6. Evaluation and Reporting. (a) Within 1 year of the date of this

order, and on an annual basis thereafter, the Secretary shall submit a report

to the President, through the APST and the Director of the Office of Manage-

ment and Budget, describing:

(i) the Platform’s operational status and capabilities;

(ii) progress toward integration across DOE national laboratories and other

participating Federal research partners, including shared access to com-

puting resources, data infrastructure, and research facilities;

(iii) the status of user engagement, including participation of student re-

searchers and any related training;

(iv) updates on research efforts and outcomes achieved, including measur-

able scientific advances, publications, and prototype technologies;

(v) the scope and outcomes of public-private partnerships, including col-

laborative research projects and any technology transitions or commer-

cialization activities; and

(vi) any identified needs or recommendations for authorities or interagency

support to achieve the Mission’s objectives.

Sec. 7. General Provisions. (a) Nothing in this order shall be construed

to impair or otherwise affect:

(i) the authority granted by law to an executive department or agency,

or the head thereof; or

(ii) the functions of the Director of the Office of Management and Budget

relating to budgetary, administrative, or legislative proposals.

(b) This order shall be implemented consistent with applicable law and

subject to the availability of appropriations.

(c) This order is not intended to, and does not, create any right or benefit,

substantive or procedural, enforceable at law or in equity by any party

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against the United States, its departments, agencies, or entities, its officers,

employees, or agents, or any other person.

(d) The costs for publication of this order shall be borne by the Department

of Energy.

THE WHITE HOUSE,

November 24, 2025.

[FR Doc. 2025–21665

Filed 11–26–25; 11:15 am]

Billing code 6450–01–P

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